骨关节炎
伤害感受器
感觉系统
医学
软骨下骨
神经科学
伤害
解剖
病理
关节软骨
心理学
内科学
受体
替代医学
作者
Michael Morgan,Vida Nazemian,Kate Harrington,Jason Ivanusic
标识
DOI:10.3389/fendo.2022.1047943
摘要
Osteoarthritis pain is often thought of as a pain driven by nerves that innervate the soft tissues of the joint, but there is emerging evidence for a role for nerves that innervate the underlying bone. In this mini review we cite evidence that subchondral bone lesions are associated with pain in osteoarthritis. We explore recent studies that provide evidence that sensory neurons that innervate bone are nociceptors that signal pain and can be sensitized in osteoarthritis. Finally, we describe neuronal remodeling of sensory and sympathetic nerves in bone and discuss how these processes can contribute to osteoarthritis pain.
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