G蛋白偶联胆汁酸受体
法尼甾体X受体
胆汁酸
化学
鹅去氧胆酸
熊去氧胆酸
核受体
牛磺酸
胆酸
受体
生物化学
氨基酸
基因
转录因子
作者
Andreas Luxenburger,Lawrence D. Harris,Elizabeth M. Ure,Wanting Jiao,Anthony D. Woolhouse,Scott A. Cameron,Alexander C. Weymouth‐Wilson,Richard H. Furneaux,Janet L. Pitman,Simon F.R. Hinkley
标识
DOI:10.1016/j.ejmech.2023.115143
摘要
Recent discoveries have demonstrated that the physiological function of bile acids extends to the regulation of diverse signaling processes through interactions with nuclear and G protein-coupled receptors, most notably the Farnesoid-X nuclear receptor (FXR) and the G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5). Targeting such signaling pathways pharmacologically, i.e. with bile acid-derived therapeutics, presents great potential for the treatment of various metabolic, inflammatory immune, liver, and neurodegenerative diseases. Here we report the discovery of two potent and selective TGR5 agonists (NZP196 and 917). These compounds are the taurine conjugates of 6α-ethyl-substituted 12β-methyl-18-nor-bile acids with the side chain being located on the α-face of the steroid scaffold. The compounds emerged from a screening effort of a diverse library of 12β-methyl-18-nor-bile acids that were synthesized from 12β-methyl-18-nor-chenodeoxycholic acid and its C17-epimer. Upon testing for FXR activity, both compounds were found to be inactive, thus revealing selectivity for TGR5.
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