The role of neural self-referential processes underlying self-concept in adolescent depression: A comprehensive review and proposed neurobehavioral model

There is growing knowledge about how self-concept develops in adolescence and contributes to the onset of depression, but researchers have only recently begun investigating the neural mechanisms that underlie self-referential cognition in adolescents with and without depression. This paper reviews task-related functional neuroimaging (fMRI) research on self-referential neural processing in both healthy and depressed adolescents (Mage range = 12-18 years), with a focus on elucidating brain activation that may subserve adolescent self-perception and related associations with depression. Drawing on conclusions from the affective neuroscience literature and developmental theory, we propose a neurobehavioral model and future research recommendations to address how social factors might shape self-referential neural processes and self-concept in ways that confer risk for depression. We review the operationalization of self-concept, developmental theory (i.e., symbolic interactionism) on self-concept development, and the role of self-concept in adolescent depression. We then review empirical studies assessing neural activation during healthy and depressed adolescents' processing of self-relevant information, and the limited studies assessing links between social factors and neural self-referential processing.