视网膜
生物
基因
基因表达
视网膜
感光细胞
核糖核酸
遗传学
细胞生物学
计算生物学
神经科学
生物化学
作者
Lulin Huang,Runze Li,Lin Ye,Shanshan Zhang,Huaping Tian,Mingyan Du,Chao Qu,Shujin Li,Jie Li,Mei Yang,Bing-Fei Wu,Ran Chen,Guo Huang,Ling Zhong,Hongjie Yang,Man Yu,Yi Shi,Changguan Wang,Houbin Zhang,Wei Chen,Zhenglin Yang
标识
DOI:10.1007/s11427-021-2163-1
摘要
The human retina serves as a light detector and signals transmission tissue. Advanced insights into retinal disease mechanisms and therapeutic strategies require a deep understanding of healthy retina molecular events. Here, we sequenced the mRNA of over 0.6 million single cells from human retinas across six regions at nine different ages. Sixty cell sub-types have been identified from the human mature retinas with unique markers. We revealed regional and age differences of gene expression profiles within the human retina. Cell-cell interaction analysis indicated a rich synaptic connection within the retinal cells. Gene expression regulon analysis revealed the specific expression of transcription factors and their regulated genes in human retina cell types. Some of the gene’s expression, such as DKK3, are elevated in aged retinas. A further functional investigation suggested that over expression of DKK3 could impact mitochondrial stability. Overall, decoding the molecular dynamic architecture of the human retina improves our understanding of the vision system.
科研通智能强力驱动
Strongly Powered by AbleSci AI