Methoxycarbonylmethanesulfonyl Chloride

[56146-83-9] C3H5ClO4S (MW 172.60) InChI = 1S/C3H5ClO4S/c1-8-3(5)2-9(4,6)7/h2H2,1H3 InChIKey = YBIPZPBGAGTBGK-UHFFFAOYSA-N (synthesis of sultam analogs of β-lactams;3 synthesis of biologically active sulfonamides4-6) Physical Data: bp 98 °C/8 mm Hg; d 1.505 g cm−3; fp >110 °C. Solubility: sol C6H6, CH2Cl2, Et2O. Form Supplied in: colorless liquid. Analysis of Reagent Purity: reagent purity may be determined by standard analytical techniques. Preparative Methods: from chlorosulfonylacetyl chloride by reaction with 1 equiv of methanol;1 may also be prepared by chlorination of sodium methoxycarbonylmethanesulfonate with Phosphorus(V) Chloride2 or by direct chlorination of methyl thioglycolate.3 Purification: distillation under reduced pressure. Handling, Storage, and Precautions: moisture sensitive; causes burns.