RNA剪接
选择性拼接
计算生物学
信使核糖核酸
翻译(生物学)
癌症疫苗
鉴定(生物学)
生物
癌症
核糖核酸
基因
遗传学
免疫疗法
植物
作者
Rui Cheng,Zhaochun Xu,Meng Luo,Ping-ping Wang,Huimin Cao,Xiyun Jin,Wenyang Zhou,Lixing Xiao,Qinghua Jiang
摘要
Messenger RNA (mRNA) vaccines have shown great potential for anti-tumor therapy due to the advantages in safety, efficacy and industrial production. However, it remains a challenge to identify suitable cancer neoantigens that can be targeted for mRNA vaccines. Abnormal alternative splicing occurs in a variety of tumors, which may result in the translation of abnormal transcripts into tumor-specific proteins. High-throughput technologies make it possible for systematic characterization of alternative splicing as a source of suitable target neoantigens for mRNA vaccine development. Here, we summarized difficulties and challenges for identifying alternative splicing-derived cancer neoantigens from RNA-seq data and proposed a conceptual framework for designing personalized mRNA vaccines based on alternative splicing-derived cancer neoantigens. In addition, several points were presented to spark further discussion toward improving the identification of alternative splicing-derived cancer neoantigens.
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