KEAP1型
细胞保护
医学
氧化应激
肿瘤促进
癌症
癌症研究
晋升(国际象棋)
细胞生物学
生物信息学
基因
内科学
生物
生物化学
转录因子
癌变
法学
政治学
政治
作者
Poorti Pandey,Alok Kumar Singh,Manjeet Singh,Mallika Tewari,H. S. Shukla,Indrajeet Singh Gambhir
标识
DOI:10.1016/j.critrevonc.2017.02.006
摘要
Keap1-Nrf2 pathway is continuously involved in the cytoprotection from oxidative stress generated due to various factors either extrinsic or intrinsic in origin. This role of Nrf2 in the response to oxidative stress is well established. Following oxidative insult, Nrf2 mediates the regulation of the inducible expression of cytoprotective genes. The level and functional capacity of Nrf2 is regulated at the post-transcriptional level, mainly through its association with an actin-associated protein, Keap1. Various studies reported that any discrepancy from their routine may lead to promotion of tumor as well. So there is need to explore their role in cytoprotection and tumor promotion if any. This review is an attempt to critically analyze the available data that may lighten up the present knowledge and unveil the new regime for cancer prevention and treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI