内质网
未折叠蛋白反应
生物
细胞生物学
免疫系统
免疫
自身免疫
平衡
信号转导
神经科学
免疫学
作者
Sarah E. Bettigole,Laurie H. Glimcher
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2015-03-21
卷期号:33 (1): 107-138
被引量:362
标识
DOI:10.1146/annurev-immunol-032414-112116
摘要
Immune responses occur in the midst of a variety of cellular stresses that can severely perturb endoplasmic reticulum (ER) function. The unfolded protein response is a three-pronged signaling axis dedicated to preserving ER homeostasis. In this review, we highlight many important and emerging functional roles for ER stress in immunity, focusing on how the bidirectional cross talk between immunological processes and basic cell biology leads to pleiotropic signaling outcomes and enhanced sensitivity to inflammatory stimuli. We also discuss how dysregulated ER stress responses can provoke many diseases, including autoimmunity, firmly positioning the unfolded protein response as a major therapeutic target in human disease.
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