法尼基二磷酸合酶
麦角甾醇
法尼醇
生物化学
酵母
突变体
酿酒酵母
酶
生物
甲戊酸途径
营养不良
甲戊酸
生物合成
化学
基因
作者
Christophe Chambon,Véronique Ladevèze,Madeleine Servouse,Laurence Blanchard,Catherine Javelof,B. Vladescu,Francis Karst
出处
期刊:Lipids
[Wiley]
日期:1991-08-01
卷期号:26 (8): 633-636
被引量:57
摘要
Yeast mutant strains auxotrophic for ergosterol and blocked in mevalonate diphosphate decarboxylase (erg19) and farnesyl diphosphate (FPP) synthetase (erg20) were isolated. The main feature of the mutants blocked in FPP synthetase is their ability to excrete prenyl alcohols, such as geraniol and farnesol. The isolation of the functional ERG20 gene allowed us to show that farnesyl diphosphate synthetase could be a rate limiting enzyme in ergosterol biosynthesis in yeast.
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