癌症研究
医学
生物
癌症
内科学
肿瘤微环境
肠道菌群
胰腺癌
结直肠癌
微生物群
作者
Sharmeen Chagani,Lawrence N. Kwong
出处
期刊:Cancer Discovery
[American Association for Cancer Research]
日期:2021-05-01
卷期号:11 (5): 1014-1015
标识
DOI:10.1158/2159-8290.cd-21-0187
摘要
Primary sclerosing cholangitis and colitis are known predisposing factors for bile duct cancer, but their exact pro-oncogenic mechanisms are unclear. In this issue of Cancer Discovery, Zhang and colleagues identify intestinal barrier impairment as a key mechanism, resulting in gut microbes spilling into the portal vein, in turn recruiting immunosuppressive myeloid-derived suppressor cells and promoting cholangiocarcinoma.See related article by Zhang et al. p. 1248.
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