尿路上皮
个性化医疗
病理
尿路上皮癌
膀胱癌
医学
疾病
癌
精密医学
分子病理学
膀胱
生物
癌症研究
基因
肿瘤科
癌症
内科学
生物信息学
遗传学
作者
Antonio López-Beltrán,Alessia Cimadamore,Rodolfo Montironi,Liang Cheng
标识
DOI:10.1016/j.humpath.2021.04.001
摘要
The current personalized oncology era has witnessed significant efforts to integrate clinical, pathological, and molecular classifications. The growing need for molecular biomarkers to feed personalized oncology, together with the unprecedented wealth of knowledge on the molecular basis of bladder cancer, has led to a novel approach to this disease, incorporating molecularly generated data in clinical practice for locally advanced or metastatic disease. Translational research allows a better understanding of the early events in the development of urothelial carcinoma in the urinary bladder. Thus, mutations in the KMT2D and KDM6A chromatin-modifying genes confer competitive advantages that drive cells to colonize larger regions of the urothelium. Additional mutations in TP53, PIK3CA, FGFR3, or RB1 genes then trigger the process of malignant transformation in the urothelium. In the current review, we provide an overview of what could be the expected transition from the morphology-based classification to a combined, molecularly enriched reporting of clinically meaningful parameters aiming to promote personalized oncology of urothelial carcinoma.
科研通智能强力驱动
Strongly Powered by AbleSci AI