炎症体
NALP3
先天免疫系统
促炎细胞因子
目标2
半胱氨酸蛋白酶1
生物
白细胞介素18
细胞生物学
免疫系统
炎症
免疫学
免疫
细胞因子
作者
Virginie Pétrilli,Catherine Dostert,Daniel A. Muruve,Jürg Tschopp
标识
DOI:10.1016/j.coi.2007.09.002
摘要
The NOD-like receptors (NLR) are a family of intracellular sensors of microbial motifs and 'danger signals' that have emerged as being crucial components of the innate immune responses and inflammation. Several NLRs (NALPs and IPAF) form a caspase-1-activating multiprotein complex, termed inflammasome, that processes proinflammatory cytokines including IL-1beta. Amongst the various inflammasomes, the NALP3 inflammasome is particularly qualified to sense a plethora of diverse molecules, ranging from bacterial muramyldipeptide to monosodium urate crystals. The important role of the NALP3 inflammasome is emphasized by the identification of mutations in the NALP3 gene that are associated with a susceptibility to inflammatory disorders. These and other issues related to the inflammasome are discussed in this review.
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