拉格2
重组激活基因
V(D)J复合
重组酶
染色质
生物
重组信号序列
重组
基因重排
基因组不稳定性
谱系(遗传)
细胞生物学
基因
劈理(地质)
遗传学
DNA
DNA损伤
古生物学
断裂(地质)
作者
David G. Schatz,Yanhong Ji
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2011-03-11
卷期号:11 (4): 251-263
被引量:501
摘要
The initiation of V(D)J recombination by the recombination activating gene 1 (RAG1) and RAG2 proteins is carefully orchestrated to ensure that antigen receptor gene assembly occurs in the appropriate cell lineage and in the proper developmental order. Here we review recent advances in our understanding of how DNA binding and cleavage by the RAG proteins are regulated by the chromatin structure and architecture of antigen receptor genes. These advances suggest novel mechanisms for both the targeting and the mistargeting of V(D)J recombination, and have implications for how these events contribute to genome instability and lymphoid malignancy.
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