胍
试剂
化学
溶剂
水溶液
异硫氰酸盐
碘
胶束
肺表面活性物质
高价分子
组合化学
有机化学
生物化学
作者
Jakkrit Srisa,Theeranon Tankam,Mongkol Sukwattanasinitt,Sumrit Wacharasindhu
标识
DOI:10.1002/asia.201900982
摘要
Abstract In this work, we developed a one‐pot synthesis of guanidine directly from isothiocyanate using DIB (diacetoxyiodobenzene) as a desulfurizing agent under micellar conditions in water. Our optimization study revealed that the use of 1 % TPGS‐750‐M as a surfactant with NaOH as an additive base at room temperature can convert a variety of isothiocyanates and amines into corresponding guanidines in excellent yields (69 – 95 %). This synthetic process in water can be applied to prepare guanidine at gram‐scale quantity. Our aqueous micellar medium also demonstrated high reusability as the reaction can be performed for several cycles without losing its efficiency. The reaction is metal‐free, utilizes water as solvent and practical (room temperature and open flask).
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