松萝酸
MPTP公司
神经保护
神经炎症
帕金森病
星形胶质细胞
药理学
医学
化学
神经科学
生物
内科学
病理
中枢神经系统
疾病
地衣
植物
作者
Seulah Lee,Yujeong Lee,Sugyeong Ha,Hae Young Chung,Hangun Kim,Jae‐Seoun Hur,Jaewon Lee
出处
期刊:Brain Research
[Elsevier]
日期:2020-03-01
卷期号:1730: 146642-146642
被引量:19
标识
DOI:10.1016/j.brainres.2019.146642
摘要
Neuroinflammation is often associated with astrocyte and microglial activations particularly in Parkinson's disease (PD) and other brain damage such as Alzheimer's disease. Therefore, the modulation of glial activation offers a possible target for treating PD-associated pathologies. Here, we evaluated the neuroprotective effects of usnic acid, a naturally occurring dibenzofuran derivative found in several lichen species in an acute mouse model of PD. Male mice were administered with vehicle or usnic acid (5 or 25 mg/kg) for 10 consecutive days, and then on day 11, MPTP (20 mg/kg, i.p.) was administered four times (with 2 hrs intervals between injections) to induce PD pathologies. It was found that MPTP-induced motor dysfunction and neuronal loss were ameliorated in the usnic acid-treated mice versus vehicle-treated controls. Further study revealed that usnic acid effectively inhibited MPP+-induced glial activation in primary astrocytes by blocking NF-κB activation. Taken together, these findings suggest that usnic acid could be considered potentially useful therapeutic candidates for PD and other neurodegenerative diseases associated with neuroinflammation.
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