根茎
苍术
传统医学
化学
立体化学
萜烯
医学
病理
中医药
替代医学
作者
Yi-nan Zhao,Gai Gao,Junxia Ma,Rui-Zhu Xu,Tao Guo,Li-min Wu,Xinguang Liu,Zhishen Xie,Jiangyan Xu,Zhenqiang Zhang,Pan Wang
标识
DOI:10.1080/14786419.2020.1869970
摘要
Two new sesquiterpenes, named selina-4(14),7,11-trien-9-ol (1) and selina-4(14),11-dien-7-ol (2), along with two known compounds were isolated from rhizomes of Atractylodes macrocephala Koidz. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of 1 was established by TDDFT-ECD calculations. Compound 1 was found to moderately inhibit LSD1 activity with IC50 value of 34.0 μM. Compounds 1 and 4 exhibited a regulate effect on Keap1-Nrf2-ARE pathway.[Formula: see text].
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