Neuron-antibody mediated movement disorders

Neuron-antibody mediated movement disorders are a class of movement disorders caused by abnormal immune responses to nerve auto-antigens,which could be paraneoplastic, infectious or idiopathic. The clinical manifestations of nervous system symptoms varied, and movement disorders can be used as part of various phenotypes, including chorea, dystonia, Parkinson′s syndrome, myoclonus, stiffness syndrome, autoimmune encephalitis and cerebellar ataxia and so on. The clinical diagnosis of this disease is mainly based on the positive specific anti-central or peripheral nerve autoantibodies in serum or cerebrospinal fluid. The specificity of antibodies helps to predict associated cancer and its response to immunotherapy. Early and accurate diagnosis is very important because of the good therapeutic effect of early immunization. Key words: Antibodies; Autoimmunity; Movement disorders; Immunotherapy