ФЕНОТИПИЧЕСКИЙ ПРОФИЛЬ CD64–CD16⁺CD32⁺CD11b⁺, CD64⁺CD16⁺CD32⁺CD11b⁺ СУБПОПУЛЯЦИЙ НЕЙТРОФИЛЬНЫХ ГРАНУЛОЦИТОВ У ЗДОРОВЫХ НОВОРОЖДЕННЫХ, УСЛОВНО-ЗДОРОВЫХ ДЕТЕЙ РАЗЛИЧНЫХ ВОЗРАСТНЫХ ГРУПП И УСЛОВНОЗДОРОВЫХ ВЗРОСЛЫХ СУБЪЕКТОВ

Neutrophilic granulocytes (NG) with different receptor equipment are heterogeneous subpopulations that have differences in their biological properties and role in the pathogenesis of immune diseases. In result of research we obtained new data on the phenotypic features of NG subpopulations carrying the CD64, CD32, CD16 and CD11b molecules in newborns and children compared to the group of adult healthy individuals. It has been established that in the peripheral blood of healthy full-term newborns, conditionally healthy children of different age and conditionally healthy adults there are two main subpopulations of circulate NG – major with СD64–CD16+CD32+CD11b+ phenotype and minor СD64+CD16+CD32+CD11b+ phenotype, different receptor expression density noted in both subpopulations. It was shown that each of the studied groups has its own phenotypic profile, possibly optimal for performing NG eff ector functions. In newborns are identified phenotypes СD64–CD16 dim CD32 dim CD11 bbright NG and СD64 dim CD16 mid CD32 bright CD11 bbright NG, in children 2–4 years old СD64–CD16 bright CD32 dim CD11 bbright NG and СD64 mid CD16 bright CD32 dim CD11 bbright NG, in children 5–9 years old СD64–CD16 mid CD32 dim CD11 bdim NG and СD64 dim CD16 bright CD32 mid CD11 bdim NG, in conditionally healthy adults СD64–CD16 mid CD32 dim CD11 bdim NG and СD64 bright CD16 dim CD32 mid CD11 bdim NG. Study shown that the NG of newborns and children of different age groups have a similar expression density of the CD64, CD16, CD32, CD11b receptors in major and minor subpopulations, NG subpopulations of healthy adults are equipped differently. The study of receptors in physiological according to age-related features is necessary for the correct interpretation of the transformation of the phenotype, changes in surface receptors expression in various pathological conditions.