In silico docking studies of alpha amylase inhibitory activity of some commercially available flavonoids

Diabetes mellitus is a metabolic disease characterized by hyperglycemia resulting from fault in insulin secretion, insulin action or both.Most effective treatment for type II diabetes is the control of postprandial hyperglycemia after a meal.Stabilization of blood glucose is necessary for diabetic patients, because it preventshyperglycemia and the complexity associated with diabetes [1].The properties of diabetes mellitus consist of long-term injury, dysfunction and failure of various organs [2].At the current situation it is predicted that 150 million people, universally have diabetes and that this will increase to 300 million by 2050 [3].Modern medicines such as sulfonylureas, biguanides, and thiozolidinediones are intended for the treatment of diabetes.Though, they also have undesired effects related with their uses [4].The natural products or medicinal plants reduce the absorption of glucose by reduce the carbohydrate hydrolyzing enzymes, such as pancreatic amylase.The inhibition of this enzyme slow down the carbohydrate digestion and extend the overall carbohydrate digestion time, ensuing in the decrease in glucose absorption rate and as a result reduce the postprandial plasma glucose rise.Several indigenous medicinal plants have a great potential in the -amylase inhibition [5].Flavonoids are a different group of metabolitederivative familiar for having a range of human healthpromoting actions [6].Several researches of flavonoids gives the details about their valuable biological activities, such as anti-allergenic, anti-cancer, anti-inflammatory, anti-oxidant, anti-viral, and vasodilating properties [7-9].However, the in silico approach of the flavonoids on the -amylase were not been characterized.The current study is to predict the in silico evaluation of -amylase inhibitory activity and the stereochemistry binding of the flavonoids on -amylase has been carried out, which may helpful in the development of potent -amylase inhibitors.