Experimental study on the expression of NMDAR1 in hippocampus of the aged epilepsy rats induced by kainic acid

Objective To observe the expression of NMDAR1 in hippocampus of the aged epilepsy rats.Methods the aged epilepsy rat models were made by injecting kainic acid into amygdala under stereotactic instrument,60 male Wistar rats were divided randomly into 6 groups. 1 the normal control group;2 the false operation group;3-6 epilepsy group.NMDAR1mRNA in situs hybridization of brian tissue were tested .Results In the normal group and false operation group,NMDAR1 positive cells distributed rarely in hippocampus;NMDAR1mRNA positive cells of epilepsy groups were significantly higher in hippocampus CA1,CA3,and dentate gyrus.Conclusions NMDAR1mRNA expressed in rat hippocampus in different degree,they were up-regulated in the aged epilepsy rats .