Tremendous progress has been made in type 2 diabetes treatment.Medication for different mechanisms continues as the pathogenesis of type 2 diabetes has been explored,maximally meeting the needs of patients.This article describes the development of medication treatment for type 2 diabetes,focusing on the discovery and research hotspots of new antidiabetic medication like GLP-1 receptor agonists,DPP-4 inhibitors and SGLT-2 inhibitors.