Humanized antibody instead of mouse monoclonal antibody for mouse monoclonal antibody can cause immune effect. Mouse monoclonal antibody has greatly impacted the development of research on human disease. Antibody techniques have developed from chimerism antibody and reshaped antibody humanized antibody. Antibody humanization has become an attracted significant research. Moreover,there is much medicine of Humanized antibody on the stage of clinical use or research. Recent progress on clinical uses and research of Humanized antibody are more important.