According to orthogonal experiment designation,the preparation technique of potato starch micro-sphere was studied.The optimum parameters were screened as starch latex at 0.45 g/mL,pH 10,0.8 g of Span60,160 mL of plant oil,0.4 g of ammonium peroxydisulfate,0.4 g of sodium hydrogen sulfite,0.15 g of N,N-methylenebisacrylamide,stirring rate at 350 r/min,crossing temperature at 50 ℃and crossing time for 2 h.The prepared starch micro-sphere had 1.924 g/g of carrier medicine adsorption.