Listeria monocytogenes(LM) is an important food-borne pathogen for animal and human's listeriosis.The pathogenicity of LM is closely correlated with virulence factors.Studying the virulence factors has important meaning to understand the pathogenic mechanism thoroughly and to prevent and cure listeriosis efficiently.The article reviewed the virulence factors(LLO,ActA,PLC,Inl,p60,Ami,PrfA,VirR,and so on)and the pathogenic mechanism of LM.