Studies showed that extracellular secretions of Xanthomonas citri had certain abilities to regulate the interaction between the bacterium and Seedwax, a fungicide. The secretions, especially extracellular polysaccharide (EPS), could strongly antagonize the inhibition of Seedwax. Output of electrolyte, EPS, extracellular protein, and bioactivity of extracellular hydrolytic enzymes are regularized to vary with the concentration of Seedwax. The results indicated that the pathogenic bacteria possess an active echo to the adverse environment by chan ging the attributions of extracellular secretions when surrounded by fungicides.