Advances in studies on apoptosis-inducing effects of golgi apparatus in oxidative stress

As an important organelle inside a cell, golgi apparatus is involved in the physiological activities like the processing and modiifcation of proteins, metabolism of lipids and vesicular transportation. Besides, it plays an important role in the ion homeostasis and stresses. In oxidative stress, the golgi apparatus undergoes the golgi apparatus stress (GA stress). hTerefore, the Ca2+/Mn2+ pump activities will alter and GA Ca2+/Mn2+ dyshomeostasis will occur functionally. Structurally, the golgi apparatus will fragment and release the stress-induced fragmentation products. Behavior mentioned above will initiate the relevant apoptotic pathway of the golgi apparatus which mediates its apoptosis. p115 (golgi-vesicular transport protein) is a stress-associated protein; fragments derived from the p115 will exert the apoptosis-inducing effects by inducing the phosphorylation of p53 in oxidative stress.