Triple therapy with esomeprazole,gatifloxacin and furazolidone for eradication of Helicobacter pylori infection

Objective To investigate the efficacy of one week combined esomeprazole,gatifloxacin and furazolilone in eradication of Helicobacter pylori.Methods Eighty patients with H.pylori-infected duodenal ulcer were randomly divided into two groups.Treatment group(Group A) received esomeprazole 40 mg,one time daily and gatifloxacin 200 mg,furazolidone 100 mg twice a day.Control group(Group B) received esomeprazole 40 mg one time a day and clarithromycin 500 mg,furazolidone 100 mg twice a day.After 1 week,both groups received esomeprazole 40 mg for 3 weeks.All patients were observed by endoscopy in four weeks after treatment.Results The eradication rates of H.pylori in group A and group B were 95% and 87.5% respectively;the cure rates were 97.5% and 95%,respectively.There were no significant differences in the eradication rate of H.pylori and cure rate between the two groups(P0.05).Conclusion Triple therapy using combined esomeprazole,gatifloxacin and furazolidone is effective and without side-effects in eradication of Helicobacter pylori infection and treatment of patients with duodenal ulcer.