Diabetes mellitus remains a major global health challenge characterized by chronic metabolic dysregulation and the risk of severe complications. Conventional therapeutic strategies often face limitations related to drug bioavailability, poor glycemic control, and patient compliance. In this regard, nanotechnology has become a promising interdisciplinary field offering innovative solutions for improved diabetes management. This chapter explores the convergence of nanoscience, bioengineering, computational modeling, and digital health technologies in developing advanced therapeutic and diagnostic platforms. Key areas discussed include smart nanocarriers for precision drug delivery, nano-enabled biosensing systems for continuous metabolic monitoring, and nanotechnology-based strategies for modulating oxidative stress, inflammation, and gut microbiota. The chapter also highlights emerging developments such as AI-guided nanomedicine design, wearable nanosensors, and autonomous drug delivery systems. Additionally, translational issues associated with clinical integration, regulatory environment, and safety considerations are discussed. Overall, interdisciplinary nanotechnology approaches hold significant potential to enable more personalized, efficient, and responsive strategies for diagnosis and treatment.