巨噬细胞
炎症
脂毒性
清道夫受体
脂质代谢
细胞生物学
脂质信号
平衡
受体
脂肪组织
生物
传出细胞增多
CD36
泡沫电池
免疫学
生物化学
内分泌学
胆固醇
糖尿病
体外
脂蛋白
胰岛素抵抗
作者
Andrea Vogel,Julia Brunner,Alexander Hajto,Omar Sharif,Gernot Schabbauer
标识
DOI:10.1016/j.bbalip.2021.159066
摘要
Macrophages are professional phagocytes, indispensable for maintenance of tissue homeostasis and integrity. Depending on their resident tissue, macrophages are exposed to highly diverse metabolic environments. Adapted to their niche, they can contribute to local metabolic turnover through metabolite uptake, conversion, storage and release. Disturbances in tissue homeostasis caused by infection, inflammation or damage dramatically alter the local milieu, impacting macrophage activation status and metabolism. In the case of persisting stimuli, defective macrophage responses ensue, which can promote tissue damage and disease. Especially relevant herein are disbalances in lipid rich environments, where macrophages are crucially involved in lipid uptake and turnover, preventing lipotoxicity. Lipid uptake is to a large extent facilitated by macrophage expressed scavenger receptors that are dynamically regulated and important in many metabolic diseases. Here, we review the receptors mediating lipid uptake and summarize recent findings on their role in health and disease. We further highlight the underlying pathways driving macrophage lipid acquisition and their impact on myeloid metabolic remodelling.
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