Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

(Cancer Cell 39, 866–882.e1–e11; June 14, 2021) In this study, Affo et al. determine origin and functions of cancer-associated fibroblasts in the liver and uncover distinct subsets that promote the growth of intrahepatic cholangiocarcinoma via different therapeutically targetable mediators. Upon publication of the original article, we realized that we had inadvertently omitted Dr. Raghu Kalluri from the author list. This has been corrected online, and the correct author list appears in print. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulationsAffo et al.Cancer CellApril 29, 2021In BriefIntrahepatic cholangiocarcinoma (ICC) is an extraordinarily stiff liver tumor due to abundant scar-forming cancer-associated fibroblasts (CAF). Here, Affo et al. determine the origin and functions of CAF, and uncover distinct CAF subsets, promoting ICC growth via different therapeutically targetable mediators. Thus, CAF and their mediators may serve as therapeutic targets for ICC. Full-Text PDF