铈
清除
材料科学
抗氧化剂
氧化铈
兴奋剂
氧化损伤
脂质过氧化
氧化磷酸化
生物相容性
制作
碳纤维
光化学
羟基自由基
化学
光催化
纳米技术
热液循环
化学工程
激进的
核化学
色散(光学)
氧化应激
纳米材料
无机化学
可见光谱
纳米颗粒
作者
Rong Cai,Long Xiao,Jianghong Qiu,Lulu Zhao,Zhuoxin Li,Huixiang Ju,Mingzhong Sun,Wenkai Zhu,Zhirong Wang,F. Du
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2021-06-23
卷期号:32 (39): 395605-395605
被引量:9
标识
DOI:10.1088/1361-6528/ac0dd9
摘要
Ferroptosis as an iron-dependent lipid peroxidation process causes sevely oxidative damage of cell, but lack of highly efficient and recycable antioxidant agents. To this end, cerium doped carbon dots (Ce-doped CDs) with radical scavenging activity were synthesized using a simple microwave-assisted hydrothermal carbonization. The resultant Ce-doped CDs exhibited an ultra-small size of only approximately 2.6 nm, excellent dispersion in water as well as optical performance. Taking advantage of inherent ultra-small size, Ce-doped CDs were endowed with high Ce3+/Ce4+ratio, which significantly enhanced their radical scavenging activity. Meanwhile, the Ce-doped CDs with superior biocompatibility could enter cells quickly and then localized in the cytoplasm. As we expected, the Ce-doped CDs strongly protected cells from oxidative damage of erastin-mediated ferroptosis. These findings suggest that the as-prepared Ce-doped CDs have the potential to be antioxidant drugs against for ferroptosis-induced oxidative damage.
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