化学
过渡金属
位阻效应
不对称氢化
同种类的
催化作用
组合化学
分子
电子效应
对映选择合成
有机化学
纳米技术
热力学
物理
材料科学
作者
Jean‐Pierre Genêt,Phannarath Phansavath,Virginie Ratovelomanana‐Vidal
标识
DOI:10.1002/ijch.202100023
摘要
Abstract This personal account focuses on the development of atropisomeric ligands and chiral transition metal complexes and their applications to the asymmetric hydrogenation of alkenes, ketones and heteroaromatics using Ru(II) and Ir(III) catalysts in‐house developed. Particularly, effective scaled‐up development syntheses of SYNPHOS and DIFLUORPHOS have been successfully achieved and their steric and electronic profiling established. Going further, we demonstrated the utility of such homogeneous catalytic process highlighted with examples of industrial applications and total syntheses of biorelevant targets. Asymmetric hydrogenation provides a powerful tool for performing precise stereocontrolled transformations on valuable complex molecules.
科研通智能强力驱动
Strongly Powered by AbleSci AI