Developmental and evolutionary dynamics of cis-regulatory elements in mouse cerebellar cells

The cerebellum reveals its genetic programs Gene-regulatory networks govern the development of organs. Sarropoulos et al . analyzed mouse cerebellar development in the context of gene-regulatory networks. Single nuclear profiles analyzing chromatin accessibility in about 90,000 cells revealed diversity in progenitor cells and genetic programs guiding cellular differentiation. The footsteps of evolution were apparent in varying constraints on different cell types. —PJH