Chemical Constituents from the Seeds of Morinda citrifolia

AIM: To investigate the chemical constituents of the seeds of M. citrifolia. METHODS: The chemical constituents from the seed of M. citrifolia were separated and purified by silica gel,Rp-18,Sephadex LH-20 column chroma-tography and Pre-TLC. Their structures were elucidated on the basis of extensive spectroscopic analysis (including 2D NMR). RESULTS: Twenty known compounds were identified as daucosterol (1),ursolic acid (2),19-hydroxyl-ursolic acid (3),1,5,15-trimethylmorindol (4),5,15-dimethyl-morindol (5),scopoletin (6),3,3'-bisdemethylpinoresinol (7),3,4,3' 4'-tetrahy-droxy-9,7'α-epoxylignano-7α,9'-lactone (8),americanin D (9),americanin A (10),americanin (11),isoprincepin (12),deace-tyl-asperulosidic acid (13),loganic acid (14),asperulosidic acid (15),rhodolatouside (16),quercetin-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (17),4-ethyl-2-hydroxyl-succinate (18),5-hydroxymethyl-2-furancarbox-aldehyde (19),3-methylbut-3-enyl-6-O-β-D-glucopyranosyl-β-D-glucopyranoside (20). CONCLUSION: Compounds 9,11,14,16 and 18 are reported from M. citrifolia for the first time.