羊毛
角蛋白
组织工程
生化工程
计算机科学
工程类
高分子科学
生物医学工程
材料科学
复合材料
医学
病理
作者
Eliza Ranjit,Stephen Hamlet,Roy George,Ajay K. Sharma,Robert M. Love
标识
DOI:10.1016/j.jsamd.2021.10.001
摘要
The use of bioactive materials has become a standard tool in the arsenal of tissue engineering and regenerative medicine applications. Bioactive materials have gained significant attention due to their ability to mimic tissues physically, chemically and mechanically. Although a plethora of both natural and synthetic polymers have been identified, wool-based keratin, which has a natural propensity to self-assemble, is biocompatible, cytocompatible, biodegradable, non-toxic and non-immunogenic, can also diminish the adhesion and growth of bacterial biofilm. Keratin based materials have subsequently been applied in various tissue engineering applications, from wound healing to drug and growth factor delivery to bone regeneration. This review focuses on the key properties of keratin, including porosity and pore size, swelling rate, degradation rate, wettability and mechanical properties responsible for its biofunctional activity, as well as recent advances in keratin-based biomaterials for biomedical applications.
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