Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach

"The Extended Hildebrand Solubility Ap - proach (EHSA) was applied in the pre - sent work to evaluate the solubility of the analgesic drug acetaminophen (paraceta - mol) in polyethylene glycol 400 + wa - ter mixtures at 298.15 K. An acceptable correlative capacity of EHSA was found using a regular polynomial model in or - der four (overall deviation below 0.7%), when the W interaction parameter is re - lated to the solubility parameter of the mixtures. Thus, the deviations obtained in the estimated solubility with respect to experimental solubility were lower than those obtained directly by means of an empiric regression of the experimental solubility as a function of the mixtures’ solubility parameters (close to 1.5%)."