灌注
药理学
吸收(声学)
空肠
新陈代谢
首过效应
管腔(解剖学)
化学
原位
止痛药
鸦片剂
回肠
医学
生物化学
内科学
材料科学
有机化学
受体
复合材料
作者
S.J. Castle,Geoffrey T. Tucker,H.F. Woods,J. C. E. Underwood,Cheryl Nicholson,Michael E. Havler,C. Lewis,Ian Flockhart,Gareth Lloyd‐Jones
出处
期刊:Journal of Pharmacological Methods
[Elsevier]
日期:1985-12-01
卷期号:14 (4): 255-274
被引量:14
标识
DOI:10.1016/0160-5402(85)90002-6
摘要
The perfused in situ rat jejunum preparation originally described by Hanson and Parsons (1976) was adapted for use in absorption and metabolism studies with drugs. The preparation allows simultaneous perfusion of the gut lumen and associated vasculature and is viable for one hour. The viability of the preparation was assessed, and the application of the method is illustrated by experiments with the opiate analgesic, buprenorphine.
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