血管生成
妊娠期糖尿病
炎症
怀孕
医学
糖尿病
内科学
内分泌学
生物信息学
免疫学
生物
妊娠期
遗传学
作者
Nikita P. Joshi,Shweta Madiwale,Deepali Sundrani,Sadhana Joshi
出处
期刊:Biochimie
[Elsevier]
日期:2023-09-01
卷期号:212: 31-40
标识
DOI:10.1016/j.biochi.2023.04.005
摘要
Gestational diabetes mellitus (GDM) is a metabolic disorder in pregnancy whose prevalence is on the rise. Reports suggest a likely association between inflammation and maternal GDM. A balance between pro and anti-inflammatory cytokines is necessary for the regulation of maternal inflammation system throughout pregnancy. Along with various inflammatory markers, fatty acids also act as pro-inflammatory molecules. However, studies reporting the role of inflammatory markers in GDM are contradictory, suggesting the need of more studies to better understand the role of inflammation in pregnancies complicated by GDM. Inflammatory response can be regulated by angiopoietins suggesting a link between inflammation and angiogenesis. Placental angiogenesis is a normal physiological process which is tightly regulated during pregnancy. Various pro and anti-angiogenic factors influence the regulation of the feto-placental vascular development. Studies evaluating the levels of angiogenic markers in women with GDM are limited and the findings are inconsistent. This review summarizes the available literature on fatty acids, inflammatory markers and angiogenesis in women with GDM. We also discuss the possible link between them and their influence on placental development in GDM.
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