Transition of Intracranial Aneurysmal Wall Enhancement from High to Low Wall Shear Stress Mediation with Size Increase: A Hemodynamic Study Based on 7T Magnetic Resonance Imaging

Abstract

Background

Wall shear stress (WSS) has been proved to be related to the formation, development and rupture of intracranial aneurysms. Aneurysm wall enhancement (AWE) on magnetic resonance imaging (MRI) can be caused by inflammation and have confirmed its relationship with low WSS. High WSS can also result in inflammation but the research of its correlation with AWE is lack because of the focus on large aneurysms limited by 3T MRI in most previous studies.This study aimed to assess the potential association between high or low WSS and AWE in different aneuryms. Especially the relationship between high WSS and AWE in small aneurysm..

Methods

Forty-three unruptured intracranial aneurysms in 42 patients were prospectively included for analysis. 7.0 T MRI was used for imaging. Aneurysm size was measured on three-dimensional time-of-flight (TOF) images. Aneurysm-to-pituitary stalk contrast ratio (CRstalk) was calculated on post-contrast black-blood T1-weighted fast spin echo sequence images. Hemodynamics were assessed by four-dimensional flow MRI.

Results

The small aneurysms group had more positive WSS–CRstalk correlation coefficient distribution (dome: 78.6%, p=0.009; body: 50.0%, p=0.025), and large group had more negative coefficient distribution (dome: 44.8%, p=0.001; body: 69.0%, p=0.002). Aneurysm size was positively correlated with the significant OSI–CRstalk correlation coefficient at the dome (p=0.012) and body (p=0.010) but negatively correlated with the significant WSS–CRstalk correlation coefficient at the dome (p<0.001) and body (p=0.017).

Conclusion

AWE can be mediated by both high and low WSS, and translate from high WSS- to low WSS-mediated pathways as size increase. Additionally, AWE may serve as an indicator of the stage of aneurysm development via different correlations with hemodynamic factors.