Design and Application of Cereblon-Recruiting Prodegraders

from a photolabile protecting group and a commonly used cathepsin-cleavable degrader-antibody conjugate (DAC) linker. Therefore, these prodegrader scaffolds introduce a generalizable conjugation strategy for CRBN-recruiting degraders to DAC linkers, eliminating the need for extensive degrader modifications to incorporate a conjugation handle. Overall, these findings establish the feasibility of utilizing glutamine analogs as a CRBN-recruiting prodegrader strategy and highlight their potential application in targeted drug delivery systems.