Digital mobility measures to predict Parkinson's disease

Parkinson's disease has a long prodromal phase 1 Berg D Postuma RB From prodromal to overt Parkinson's disease: towards a new definition in the year 2040. J Parkinsons Dis. 2018; 8: S19-S23 Crossref PubMed Scopus (11) Google Scholar during which multiple symptoms (albeit subtle) can occur, including rapid-eye-movement (REM) sleep behaviour disorder, constipation, hyposmia, and subthreshold motor symptoms. 2 Postuma RB Berg D Stern M et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord. 2015; 30: 1591-1601 Crossref PubMed Scopus (3671) Google Scholar However, these symptoms are limited as predictors of Parkinson's disease. 3 Mirelman A Saunders-Pullman R Alcalay RN et al. Application of the Movement Disorder Society prodromal criteria in healthy G2019S–LRRK2 carriers. Mov Disord. 2018; 33: 966-973 Crossref PubMed Scopus (40) Google Scholar With disease-modifying and neuroprotective therapies actively being pursued for Parkinson's disease, sensitive and specific methods to identify and stratify the people in the prodromal stage who are most likely to benefit from these therapeutic advances are urgently needed.