免疫系统
免疫学
免疫
生物
抗原
寄主(生物学)
病毒学
遗传学
作者
Hong You,Malcolm K. Jones,Catherine A. Gordon,Alexa E Arganda,Pengfei Cai,Harry Al-Wassiti,Colin W. Pouton,Donald P. McManus
摘要
Despite intensive long-term efforts, with very few exceptions, the development of effective vaccines against parasitic infections has presented considerable challenges, given the complexity of parasite life cycles, the interplay between parasites and their hosts, and their capacity to escape the host immune system and to regulate host immune responses. For many parasitic diseases, conventional vaccine platforms have generally proven ill suited, considering the complex manufacturing processes involved and the costs they incur, the inability to posttranslationally modify cloned target antigens, and the absence of long-lasting protective immunity induced by these antigens.
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