趋化因子受体
趋化因子
CCR10
受体
CCR2型
单核细胞
医学
封锁
免疫学
血管生成
趋化因子受体
癌症研究
内科学
作者
Danielle Borges Germano,Steffany Bernardo Oliveira,André Luís Lacerda Bachi,Yára Juliano,Neil Ferreira Novo,Jônatas Bussador do Amaral,Carolina Nunes França
标识
DOI:10.1016/j.imlet.2023.03.002
摘要
Chemokine receptors are fundamental in many processes related to cardiovascular diseases, such as monocyte migration to vessel walls, cell adhesion, and angiogenesis, among others. Even though many experimental studies have shown the utility of blocking these receptors or their ligands in the treatment of atherosclerosis, the findings in clinical research are still poor. Thus, in the current review we aimed to describe some promising results concerning the blockade of chemokine receptors as therapeutic targets in the treatment of cardiovascular diseases and also to discuss some challenges that need to be overcome before using these strategies in clinical practice.
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