神经可塑性
海马体
心理学
慢性应激
萧条(经济学)
下调和上调
突触可塑性
神经科学
内科学
内分泌学
医学
生物
基因
经济
生物化学
受体
宏观经济学
作者
Shuwen Yu,Yijing Zhao,Qian Luo,Bing Gu,Xixi Wang,Jinhua Cheng,Zhen Wang,Dexiang Liu,Roger Ho,Cyrus S.H. Ho
标识
DOI:10.1016/j.jpsychires.2023.12.030
摘要
Early life events are major risk factors for the onset of depression and have long-term effects on the neurobiological changes and behavioral development of rodents. However, little is known about the specific mechanisms of early life adversity in the susceptibility to subsequent stress exposure in adolescence. This study characterized the effect of maternal separation (MS), an animal model of early life adversity, on the behavioral responses to restraint stress in mice during adolescence and investigated the molecular mechanism underlying behavioral vulnerability to chronic stress induced by MS. Our results showed that MS exposure could further reinforce the depressive vulnerability to restraint stress in adolescent mice. In addition, miR-34c-5p expression was obviously up-regulated in the hippocampi of MS mice at postnatal day (P) 14 and P42. Further, synaptotagmin-1 (SYT1) was deemed as a target gene candidate of miR-34c-5p on the basis of dual luciferase assay. It was found that the downregulation of miR-34c-5p expression in the hippocampi of MS mice could ameliorate dysfunction of synaptic plasticity by targeting molecule SYT1, effects which were accompanied by alleviation of depressive and anxious behaviors in these mice. The results demonstrated that the miR-34c-5p/SYT1 pathway was involved in the susceptibility to depression induced by MS via regulating neuroplasticity in the hippocampi of mice.
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