蠕动
药物输送
体内
医学
生物医学工程
药品管理局
药品
药理学
解剖
生物
材料科学
纳米技术
生物技术
作者
Xize Gao,Jiacong Li,Jing Jing Tong,Mingjun Zhang,Jing Xu
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-01-05
卷期号:10 (1)
被引量:3
标识
DOI:10.1126/sciadv.adj7067
摘要
Biologic drugs hold immense promise for medical treatments, but their oral delivery remains a daunting challenge due to the harsh digestive environment and restricted gastrointestinal absorption. Here, inspired by the porcupinefish’s ability to inflate itself and deploy its spines for defense, we proposed an intestinal microneedle robot designed to absorb intestinal fluids for rapid inflation and inject drug-loaded microneedles into the insensate intestinal wall for drug delivery. Upon reaching the equilibrium volume, the microneedle robot leverages rhythmic peristaltic contraction for mucosa penetration. The robot’s barbed microneedles can then detach from its body during peristaltic relaxation and retain in the mucosa for drug releasing. Extensive in vivo experiments involving 14 minipigs confirmed the effectiveness of the intestinal peristalsis for microrobot actuation and demonstrated comparable insulin delivery efficacy to subcutaneous injection. The ingestible peristalsis-actuated microneedle robots may transform the oral administration of biologic drugs that primary relies on parenteral injection currently.
科研通智能强力驱动
Strongly Powered by AbleSci AI