Developing a hydroxyl-functionalized magnetic porous organic polymer combined with HPLC-MS/MS for determining 31 amide herbicides in fruit wine

• Hydrophilic magnetic porous organic polymers were successfully fabricated. • Fe 3 O 4 @SiO 2 -NH 2 @Ph-POP exhibited high adsorption capacity towards amide herbicides. • The MSPE-HPLC-MS/MS method had higher precision and lower detection limit. • Hydrogen bond and p-π stacking interaction were the primary recognition force. More and more attention has been paid to undesirable chemical contaminants from food raw materials and ingredients. The study aimed to fabricate novel hydroxyl-functionalized magnetic porous organic polymer Fe 3 O 4 @SiO 2 -NH 2 @Ph-POP and explore its use as magnetic adsorbents for magnetic solid-phase extraction (MSPE) for extracting 31 amide herbicides from fruit wine samples prior to high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Several operational parameters were optimized and the as-prepared magnetic polymer displayed favorable extraction efficiency. The method also showed low limits of detection (0.015-1.412 μg·L -1 ) and limits of quantitation (0.049-4.707 μg·L -1 ). Recoveries for all of the herbicides in four different spiked level samples were between 65.06% and 101.95% with intra-day and inter-day relative standard deviations less than 9.89% and 10.54%, respectively. The proposed MSPE-HPLC-MS/MS method was successfully applied to simultaneously determine 31 amide herbicides in fruit wine.