[Susceptible mechanisms of pulmonary mucormycosis in diabetic patients].

Pulmonary mucormycosis is a rare pulmonary fungal infectious disease. Domestic and international studies have shown that diabetes is the most common underlying condition of this disease, especially with poor glycemic control and diabetic ketoacidosis. The susceptible mechanisms of pulmonary mucormycosis in diabetic patients are closely related to hyperglycemia and diabetic ketoacidosis-induced internal environment alterations. The detailed pathogenesis includes respiratory epithelial cell damage, vascular endothelial injury, immune cell dysfunction, coagulation abnormalities, iron-rich, and high keto-acid environment in diabetic patients. Pulmonary mucormycosis always presents atypical manifestations with rapid progress and poor prognosis in patients with diabetes. This article reviews the recent research progress in the susceptible mechanisms of pulmonary mucormycosis in patients with diabetes.肺毛霉病是一种罕见的真菌感染性肺部疾病。国内外研究表明，糖尿病是该病最常见的高危因素，尤其多见于血糖控制不佳或合并酮症酸中毒患者。其易患机制主要与高血糖及酮症酸中毒引起的内环境改变有关，具体机制包括糖尿病患者的呼吸道上皮细胞损伤、血管内皮损伤、免疫细胞功能障碍、凝血功能异常以及富铁、高酮酸环境等。肺毛霉病临床表现不典型，进展迅速，病死率高。深入了解糖尿病患者肺毛霉病的易患机制对于肺毛霉病的早期预防及有效诊治具有重要意义。本文针对近年来糖尿病患者的肺毛霉病易患机制研究进行综述。.