细胞生物学
巨噬细胞
巨噬细胞极化
生物
炎症
伤口愈合
祖细胞
单核吞噬细胞系统
干细胞
免疫学
体外
生物化学
作者
Alberto Mantovani,Subhra K. Biswas,Maria Rosaria Galdiero,Antonio Sica,Massimo Locati
摘要
Abstract Mononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M2 or an M2 ‐like activation mode. Macrophages are credited with an essential role in remodelling during ontogenesis. In extraembryonic life, under homeostatic conditions, the macrophage trophic and remodelling functions are recapitulated in tissues such as bone, mammary gland, decidua and placenta. In pathology, macrophages are key components of tissue repair and remodelling that occur during wound healing, allergy, parasite infection and cancer. Interaction with cells bearing stem or progenitor cell properties is likely an important component of the role of macrophages in repair and remodelling. These properties of cells of the monocyte–macrophage lineage may represent a tool and a target for therapeutic exploitation.
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