单线态氧
光动力疗法
合理设计
双光子激发显微术
双光子吸收
荧光
吸收(声学)
光化学
体内
分子
化学
荧光寿命成像显微镜
材料科学
纳米技术
激光器
氧气
光学
有机化学
复合材料
生物技术
物理
生物
作者
Chun‐Lin Sun,Jun Li,Xiaozhen Wang,Rong Shen,Sha Li,Jian‐Qiao Jiang,Ting Li,Qi‐Wei Song,Qing Liao,Hongbing Fu,Jiannian Yao,Hao‐Li Zhang
出处
期刊:Chem
[Elsevier]
日期:2019-03-01
卷期号:5 (3): 600-616
被引量:48
标识
DOI:10.1016/j.chempr.2018.12.001
摘要
The rational design of two-photon absorption (2PA) organic dyes with 2PA cross-section (δ) values tunable by mild stimuli under physiological conditions remains a challenge. Using a simulation-assisted structure screening method, we have designed an acetal terminated distyrylbenzene derivative (Ace-DSB), which can be readily converted into aldehyde terminated molecules (Ald-DSB) to exhibit a significant increase in δ values at 760 nm. The conversion reaction, which dramatically turns on the 2PA absorption capability of the molecules, can occur in an intracellular environment. Furthermore, Ald-DSB exhibits 40 times higher efficiency of two-photon generation of singlet oxygen than Ace-DSB. These turn-on features allow enhanced two-photon laser confocal scanning microscopic imaging and two-photon excited photodynamic therapy (2PE-PDT) for MCF-7 cancer cells and melanoma tumors. This work opens a new avenue toward the design of turn-on-type two-photon absorption molecules for both in vitro and in vivo tumor imaging and 2PA-PDT.
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