化学
光化学
苯乙炔
氧化还原
试剂
烯烃
光催化
自由基离子
氢键
四氢呋喃
分子
无机化学
有机化学
催化作用
离子
溶剂
作者
Li‐Zhu Wu,Jing Qiao,Zhiyao Song,Cheng Huang,Rui‐Nan Ci,Zan Liu,Bin Chen,Chen‐Ho Tung
标识
DOI:10.1002/ange.202109849
摘要
Abstract As one of the most ubiquitous bulk reagents available, the intrinsic chemical inertness of tetrahydrofuran (THF) makes direct and site‐selective C(sp 3 )−H bond activation difficult, especially under redox neutral condition. Here, we demonstrate that semiconductor quantum dots (QDs) can activate α‐C−H bond of THF via forming QDs/THF conjugates. Under visible light irradiation, the resultant alkoxyalkyl radical directly engages in radical cross‐coupling with α‐amino radical from amino C−H bonds or radical addition with alkene or phenylacetylene, respectively. In contrast to stoichiometric oxidant or hydrogen atom transfer reagents required in previous studies, the scalable benchtop approach can execute α‐C−H bond activation of THF only by a QD photocatalyst under redox‐neutral condition, thus providing a broad of value added chemicals starting from bulk THFs reagent.
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